Acap3 Gene Summary [Mouse]
Enables GTPase activator activity. Acts upstream of or within neuron migration and regulation of neuron projection development. Located in growth cone. Is expressed in several structures, including adipose tissue; brain; genitourinary system; liver; and spleen. Orthologous to human ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acap3 |
| Official Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [Source:MGI Symbol;Acc:MGI:2153589] |
| Ensembl ID | ENSMUSG00000029033 |
| Bio databases IDs | |
| Aliases | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 |
| Synonyms | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3, CENTB5, Kiaa1716-hp, mKIAA1716 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Bin/Amphiphysin/Rvs domain
- Ankyrin repeat
- BAR domain of APPL family
- Putative GTP-ase activating proteins for the small GTPase, ARF
- PH domain
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- growth cone
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity