Septin9 Gene Summary [Mouse]
Predicted to enable GTPase activity and molecular adaptor activity. Acts upstream of or within actin cytoskeleton organization and septin cytoskeleton organization. Part of septin complex. Is expressed in several structures, including branchial arch; embryo ectoderm; embryo mesenchyme; inner ear; and integumental system. Human ortholog(s) of this gene implicated in brachial plexus neuritis and colorectal cancer. Orthologous to human SEPTIN9 (septin 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin9 |
| Official Name | septin 9 [Source:MGI Symbol;Acc:MGI:1858222] |
| Ensembl ID | ENSMUSG00000059248 |
| Bio databases IDs | |
| Aliases | septin 9 |
| Synonyms | AF17q25, Eseptin, LOC103693480, MSF, MSF1, NAPB, Ov/Br septin, PNUTL4, Sep9, SEPT9, SeptD1, Septin9l1, SINT1, SLPA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Septin9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- PAR domain
- GTPase domain
- N-terminal tail
- ribosome biogenesis GTP-binding protein YsxC/EngB
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- basic domain
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- gout
- serous low malignant potential ovarian tumor
- borderline serous ovarian cancer
- hereditary disorder
- non-small cell lung cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- mucinous ovarian carcinoma
role in cell
- proliferation
- expression in
- growth
- stabilization in
- survival
- activation in
- binding in
- invasion by
- migration
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- microtubule cytoskeleton
- non-motile cilium
- presynaptic regions
- cilia
- perinuclear region
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- microtubules
- axonemes
- midbody
- cytoplasmic bridges
- cytosol
- nucleoli
- nuclear rim
- nerve ending
- actin stress fibers
- cleavage furrow
- pseudopodia
- central spindle
- mitotic spindle
- postsynaptic density
- axon terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Septin9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- perinuclear region of cytoplasm
- cell division site
- cytoplasm
- stress fiber
- actin cytoskeleton
- septin complex
- axoneme
- septin ring
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- cadherin binding
- binding, bridging