Septin6 Gene Summary [Mouse]
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Located in several cellular components, including cleavage furrow; septin cytoskeleton; and synaptic vesicle. Part of septin complex. Is active in presynapse. Is expressed in alimentary system; central nervous system; genitourinary system; sensory organ; and thymus. Orthologous to human SEPTIN6 (septin 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin6 |
| Official Name | septin 6 [Source:MGI Symbol;Acc:MGI:1888939] |
| Ensembl ID | ENSMUSG00000050379 |
| Bio databases IDs | |
| Aliases | septin 6 |
| Synonyms | 2810035H17Rik, C920001C06RIK, LOC682750, mKIAA0128, SEP2, SEPT2, SEPT6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Septin6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- androgenic alopecia
- Klinefelter syndrome
- Huntington disease
- neoplastic cell transformation
- Turner syndrome
role in cell
- development
- growth
- early cytokinesis
- binucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sperm annulus
- cytoskeleton
- presynaptic regions
- cell cortex
- midbody
- cytoplasmic bridges
- septin ring
- synaptic vesicles
- cleavage furrow
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Septin6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- spermatogenesis
- cytokinesis after mitosis
- protein localization
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell division site
- cleavage furrow
- septin collar
- synaptic vesicle
- kinetochore
- axon terminus
- septin ring
- sperm annulus
- spindle
- midbody
- septin complex
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- binding, bridging