Rgs12 Gene Summary [Mouse]
Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in termination of G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including apical dendrite; neuronal cell body; and nuclear lumen. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Predicted to colocalize with synapse. Is expressed in several structures, including heart; nervous system; placenta; trunk; and uterus. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs12 |
| Official Name | regulator of G-protein signaling 12 [Source:MGI Symbol;Acc:MGI:1918979] |
| Ensembl ID | ENSMUSG00000029101 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 12 |
| Synonyms | 1200016K18Rik, 4632412M04Rik, E130309H11, regulator of G-protein signaling 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein regulatory motif
- Domain present in PSD-95, Dlg, and ZO-1/2
- GTPase regulator
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- canonical PDZ domain
- GoLoco motif
- GTPase activator
- enzyme
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- PDZ domain
- Regulator of G protein signaling domain
- Unstructured region of RGS12
- Raf-like Ras-binding domain
- Ubl1_cv_Nsp3_N-like
- C-terminal unstructured region of RGS12
- Unstructured region between RBD and GoLoco
Pathways
Biological processes and signaling networks where the Rgs12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizoaffective disorder
- dementia
- aortic valve calcification
- metabolic syndrome X
- squamous cell cancer
- dilated cardiomyopathy
- psoriasis
- tuberculosis
- squamous-cell carcinoma
role in cell
- formation
- cross-sectional area
- surface area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- nuclear matrix
- synapse
- perikaryon
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- cytoplasm
- cytosol
- nuclear matrix
- synapse
- nucleolus
- plasma membrane
- nucleoplasm
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase activator activity
- GTPase regulator activity