Gnai3 Gene Summary [Mouse]
Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GDP binding activity; and GTPase activating protein binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of metabolic process; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in Golgi apparatus. Is expressed in early conceptus; inner ear; and oocyte. Orthologous to human GNAI3 (G protein subunit alpha i3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnai3 |
| Official Name | guanine nucleotide binding protein (G protein), alpha inhibiting 3 [Source:MGI Symbol;Acc:MGI:95773] |
| Ensembl ID | ENSMUSG00000000001 |
| Bio databases IDs | |
| Aliases | guanine nucleotide binding protein (G protein), alpha inhibiting 3 |
| Synonyms | 87U6, ARCND1, ARCODS, G alpha I3, G-I3, GI alpha3, GIP3A, Giα-3, G protein subunit alpha i3, G protein subunit α i3, G-protein α i3, G α I3, HG1A, STIMULATORY G |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnai3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G protein alpha subunit
- palmitoylation site
- GTPase domain
- GDP binding
- myristoylation sequence
- G-protein-coupled receptor binding
- GTPase
- G-protein alpha subunit
- protein domain specific binding
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Gnai3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Autophagy
- CCR3 Signaling in Eosinophils
- Chemokine Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- IL-1 Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Protein Kinase A Signaling
- Relaxin Signaling
- RhoGDI Signaling
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Sperm Motility
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- non-insulin-dependent diabetes mellitus
- androgenic alopecia
- auriculocondylar syndrome type 1
- metabolic syndrome X
- gout
- major depression
- neutrophilia
- preeclampsia
role in cell
- migration
- proliferation
- invasion by
- phosphorylation in
- activation in
- expression in
- production in
- function
- cell death
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- detergent-insoluble fractions
- detergent-soluble membrane fractions
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- Golgi region
- cell periphery
- membrane surface
- cellular membrane
- Nucleus
- Plasma Membrane
- basal bodies
- vesicles
- centrosome
- Golgi Apparatus
- midbody
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- lysosome membrane
- nucleoplasm
- nucleoli
- zymogen granules
- membrane rafts
- perikaryon
- exosomes
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnai3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- positive regulation of macroautophagy
- negative regulation of adenylate cyclase activity
- GTP metabolic process
- dopamine receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- nucleolus
- lysosomal membrane
- plasma membrane
- nucleoplasm
- endoplasmic reticulum membrane
- centrosome
- heterotrimeric G-protein complex
- extracellular vesicular exosome
- cytoplasm
- membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- GTP binding
- G-protein coupled receptor binding
- protein binding
- metal ion binding
- GTPase activity
- GDP binding
- G-protein beta/gamma-subunit complex binding