Guf1 Gene Summary [Mouse]
Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in positive regulation of translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 40. Orthologous to human GUF1 (GTP binding elongation factor GUF1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Guf1 |
| Official Name | GUF1 homolog, GTPase [Source:MGI Symbol;Acc:MGI:2140726] |
| Ensembl ID | ENSMUSG00000029208 |
| Bio databases IDs | |
| Aliases | GUF1 homolog, GTPase |
| Synonyms | 4631409J12, DEE40, EF-4, EIEE40, GTP binding elongation factor GUF1, GUF1 homolog, GTPase, mtEF4, RGD1310774 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Guf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- elongation factor 4
- Elongation Factor G, domain III
- 50S ribosome-binding GTPase
- Domain III of Elongation factor G (EF-G) and related proteins
- translation elongation factor EF-G
- Elongation factor Tu domain 2
- Elongation_Factor_C
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- small GTP-binding protein domain
- Elongation factor G C-terminus
- elongation factor G-like protein
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- GTP-binding protein LepA C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Guf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- translation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- mitochondrial ribosome binding
- GTP binding
- GTPase activity