Tuba4a Gene Summary [Mouse]
Enables enzyme binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in early embryo; lung; nervous system; and retina layer. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22. Orthologous to human TUBA4A (tubulin alpha 4a). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tuba4a |
| Official Name | tubulin, alpha 4A [Source:MGI Symbol;Acc:MGI:1095410] |
| Ensembl ID | ENSMUSG00000026202 |
| Bio databases IDs | |
| Aliases | tubulin, alpha 4A |
| Synonyms | M[a]4, Tuba4, tubulin, alpha 4A, Tubulin M-α-4, tubulin, α 4A |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tuba4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- protein kinase binding
- Tubulin/FtsZ family, GTPase domain
- enzyme binding
- protein binding
- Tubulin/FtsZ family, C-terminal domain
Pathways
Biological processes and signaling networks where the Tuba4a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cytoskeleton
- microtubules
- inner nuclear membrane