Amtn Gene Summary [Mouse]
Involved in odontogenesis of dentin-containing tooth and positive regulation of enamel mineralization. Located in basement membrane and cell-cell junction. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3B. Orthologous to human AMTN (amelotin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amtn |
| Official Name | amelotin [Source:MGI Symbol;Acc:MGI:1918671] |
| Ensembl ID | ENSMUSG00000029282 |
| Bio databases IDs | |
| Aliases | amelotin |
| Synonyms | 5430427O21Rik, AI3B, amelotin, LOC686338, UNQ689 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Amtn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Amelotin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intercellular junctions
- endoplasmic reticulum lumen
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Amtn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of enamel mineralization
- cell adhesion
- odontogenesis of dentin-containing tooth
- positive regulation of biomineral tissue development
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- basement membrane
- cell-cell junction
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding