AMTN Gene Summary [Human]
The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | AMTN |
| Official Name | amelotin [Source:HGNC Symbol;Acc:HGNC:33188] |
| Ensembl ID | ENSG00000187689 |
| Bio databases IDs | |
| Aliases | amelotin |
| Synonyms | 5430427O21Rik, AI3B, amelotin, LOC686338, UNQ689 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AMTN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Amelotin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intercellular junctions
- endoplasmic reticulum lumen
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AMTN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of enamel mineralization
- cell adhesion
- odontogenesis of dentin-containing tooth
- positive regulation of biomineral tissue development
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- basement membrane
- cell-cell junction
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding