Tgm3 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity; protein-glutamine gamma-glutamyltransferase activity; and structural molecule activity. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; musculoskeletal system; and nervous system. Orthologous to human TGM3 (transglutaminase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tgm3 |
| Official Name | transglutaminase 3, E polypeptide [Source:MGI Symbol;Acc:MGI:98732] |
| Ensembl ID | ENSMUSG00000027401 |
| Bio databases IDs | |
| Aliases | transglutaminase 3, E polypeptide |
| Synonyms | AI893889, EC 2.3.2.13, RGD1561831, TGase-3, TGase E, TG E, TG(E), Transglutaminase 3, transglutaminase 3, E polypeptide, UHS2, we |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tgm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transglutaminase-like superfamily
- Transglutaminase/protease-like homologues
- protein-glutamine gamma-glutamyltransferase
- calcium ion binding
- enzyme
- protein binding
- Transglutaminase family, C-terminal ig like domain
- structural molecule
- transferase, transferring acyl groups
- Transglutaminase family
Pathways
Biological processes and signaling networks where the Tgm3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillomatosis
- cutaneous melanoma
- cancer
- epithelial cancer
- skin cancer
- colorectal cancer
- gastric adenocarcinoma
- cutaneous melanoma cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- cell death
- differentiation
- cross-linkage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- cytoplasmic face of plasma membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tgm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- keratinocyte differentiation
- hair follicle morphogenesis
- peptide cross-linking
- keratinization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- extrinsic to internal side of plasma membrane
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- transferase activity, transferring acyl groups
- protein-glutamine gamma-glutamyltransferase activity
- catalytic activity
- calcium ion binding
- structural molecule activity