Abcb9 Gene Summary [Mouse]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may be associated with lysosome activity. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Abcb9 |
| Official Name | ATP-binding cassette, sub-family B (MDR/TAP), member 9 [Source:MGI Symbol;Acc:MGI:1861729] |
| Ensembl ID | ENSMUSG00000029408 |
| Bio databases IDs | |
| Aliases | ATP-binding cassette, sub-family B (MDR/TAP), member 9 |
| Synonyms | ATP binding cassette subfamily B member 9, ATP-binding cassette, sub-family B member 9, EST122234, mKIAA1520, TAPL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abcb9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
- Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
- phosphonate ABC transporter, ATP-binding protein
- ATP binding
- Conjugate Transporter-2 (CT2) Family protein
- heme ABC exporter, ATP-binding protein CcmA
- thiol reductant ABC exporter, CydC subunit
- energy-coupling factor transporter ATPase
- nickel import ATP-binding protein NikE
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ATPase activity, coupled to transmembrane movement of substances
- SbcC/RAD50-like, Walker B motif
- peptide-transporting ATPase
- lipid A export permease/ATP-binding protein MsbA
- protein binding
- urea ABC transporter, ATP-binding protein UrtE
- ABC transporter transmembrane region
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- thiol reductant ABC exporter, CydD subunit
- oligopeptide-transporting ATPase
- NHLM bacteriocin system ABC transporter, ATP-binding protein
- protein homodimerization
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- transporter
Pathways
Biological processes and signaling networks where the Abcb9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- osteoarthritis
- insomnia
- venous thromboembolism
- pervasive developmental disorder
- proliferative diabetic retinopathy
regulates
- peptide
role in cell
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-lysosome fractions
- membrane fraction
- intracellular membrane-bounded organelle
- cellular membrane
- lysosome
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abcb9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligopeptide transmembrane transport
- transmembrane transport
- peptide metabolic process
- protein transport
- antigen processing and presentation of peptide antigen via MHC class I
- peptide transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- oligopeptide-transporting ATPase activity
- ATPase activity, coupled to transmembrane movement of substances
- protein homodimerization activity
- protein binding
- transmembrane transporter activity
- peptide-transporting ATPase activity