Uncx Gene Summary [Mouse]
Predicted to enable sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including cartilage condensation; central nervous system development; and common myeloid progenitor cell proliferation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human UNCX (UNC homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uncx |
| Official Name | UNC homeobox [Source:MGI Symbol;Acc:MGI:108013] |
| Ensembl ID | ENSMUSG00000029546 |
| Bio databases IDs | |
| Aliases | UNC homeobox |
| Synonyms | Chx4, LOC100510018, PHD1, UNC homeobox, UNCX4.1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uncx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uncx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell differentiation
- olfactory bulb interneuron differentiation
- cartilage condensation
- dorsal spinal cord development
- regulation of gene expression
- pattern specification process
- common myeloid progenitor cell proliferation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding RNA polymerase II transcription factor activity