Rxrb Gene Summary [Mouse]
Enables chromatin DNA binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to retinoic acid. Acts upstream of or within several processes, including cardiac muscle tissue development; maternal placenta development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; sensory organ; and urinary system. Orthologous to human RXRB (retinoid X receptor beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rxrb |
| Official Name | retinoid X receptor beta [Source:MGI Symbol;Acc:MGI:98215] |
| Ensembl ID | ENSMUSG00000039656 |
| Bio databases IDs | |
| Aliases | retinoid X receptor beta |
| Synonyms | DAUDI6, H-2RIIBP, NR2B2, RCoR-1, retinoid X receptor beta, retinoid X receptor β, Rub, RXR-beta, RXR-β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rxrb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- retinoic acid receptor binding
- transcription activation domain
- AF-2 transcription activation domain
- chromatin binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- AF-1 domain
- ligand-binding domain
- ligand-dependent nuclear receptor
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- DNA binding domain
- nucleic acid binding
- C-terminal heptad repeat domain
- vitamin D receptor binding
- protein binding
- thyroid hormone receptor binding
- sequence-specific DNA binding
- DNA binding
- binding protein
- double-stranded DNA binding
- Ligand-binding domain of nuclear hormone receptor
Pathways
Biological processes and signaling networks where the Rxrb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Aryl Hydrocarbon Receptor Signaling
- Glucocorticoid Receptor Signaling
- LXR/RXR Activation
- Non-Small Cell Lung Cancer Signaling
- RAR Activation
- Retinoic acid Mediated Apoptosis Signaling
- Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency
- Small Cell Lung Cancer Signaling
- TR/RXR Activation
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- non-small cell lung cancer
- Alzheimer disease
- psoriasis
- de novo acute myeloid leukemia
- oligozoospermia
- leukemia
- prostate cancer
- laryngeal squamous cell carcinoma
- mycosis fungoides
role in cell
- formation
- expression in
- differentiation
- proliferation
- growth
- binding in
- number
- long-term potentiation
- cytostasis
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rxrb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- retinoic acid receptor signaling pathway
- response to retinoic acid
- positive regulation of transcription, DNA-dependent
- anatomical structure development
- cell differentiation
- positive regulation of vitamin D receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- steroid hormone mediated signaling pathway
- positive regulation of bone mineralization
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II regulatory region sequence-specific DNA binding
- steroid hormone receptor activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- retinoic acid-responsive element binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity