Ung Gene Summary [Mouse]
Enables uracil DNA N-glycosylase activity. Acts upstream of or within isotype switching and somatic hypermutation of immunoglobulin genes. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and olfactory epithelium. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ung |
| Official Name | uracil DNA glycosylase [Source:MGI Symbol;Acc:MGI:109352] |
| Ensembl ID | ENSMUSG00000029591 |
| Bio databases IDs | |
| Aliases | uracil DNA glycosylase |
| Synonyms | DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2, uracil-DNA glycosylase, Uracil hydrolase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ung often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- damaged DNA binding
- catalytic domain
- N-glycosyl glycosylase
- uridine nucleosidase
- uracil DNA N-glycosylase
- enzyme
- protein binding
- uracil-DNA glycosylases (UDG) and related enzymes
- ribosomal small subunit binding
Pathways
Biological processes and signaling networks where the Ung gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- cancer
- diabetic nephropathy
- small cell lung cancer
- lymphomagenesis
- B cell cancer
- B-cell neoplasia
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
role in cell
- production in
- degeneration
- phosphorylation in
- apoptosis
- damage in
- cell death
- survival
- sensitivity
- colony formation
- fragility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ung gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- isotype switching
- depyrimidination
- somatic hypermutation of immunoglobulin genes
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- uracil DNA N-glycosylase activity
- protein binding
- ribosomal small subunit binding
- damaged DNA binding