A2m Gene Summary [Mouse]
Predicted to enable several functions, including cytokine binding activity; growth factor binding activity; and serine-type endopeptidase inhibitor activity. Acts upstream of or within stem cell differentiation. Predicted to be active in extracellular space. Is expressed in several structures, including brain; embryo mesenchyme; liver; meninges; and retina. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | A2m |
| Official Name | alpha-2-macroglobulin [Source:MGI Symbol;Acc:MGI:2449119] |
| Ensembl ID | ENSMUSG00000030111 |
| Bio databases IDs | |
| Aliases | alpha-2-macroglobulin |
| Synonyms | A2mp, Alpha 2 Macroglobulin, H-2 Class I Histocompatibility Antigen Alpha-Chain, H-2 Class I Histocompatibility Antigen α-Chain, α-2-macroglobulin |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse A2m often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-2-macroglobulin bait region domain
- calcium-dependent protein binding
- cytokine binding
- protease binding
- Macroglobulin domain MG4
- serine protease inhibitor activity
- enzyme binding
- A-macroglobulin receptor binding domain
- protein binding
- receptor binding
- interleukin-1 binding
- identical protein binding
- Macroglobulin domain MG3
- endopeptidase inhibitor
- ISOPREN_C2_like
- protease inhibitor
- A-macroglobulin TED domain
- interleukin-8 binding
- growth factor binding
- Alpha-2-macroglobulin family
- MG2 domain
Pathways
Biological processes and signaling networks where the A2m gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cytosol