Hsd17b10 Gene Summary [Mouse]
Predicted to enable several functions, including amyloid-beta binding activity; nuclear estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including carboxylic acid catabolic process; mitochondrial tRNA processing; and steroid metabolic process. Located in endoplasmic reticulum and mitochondrial nucleoid. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in pheochromocytoma and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd17b10 |
| Official Name | hydroxysteroid (17-beta) dehydrogenase 10 [Source:MGI Symbol;Acc:MGI:1333871] |
| Ensembl ID | ENSMUSG00000025260 |
| Bio databases IDs | |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 10 |
| Synonyms | 17b-HSD10, ABAD, Ads9, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, HSD10, HSD10MD, hydroxysteroid (17-beta) dehydrogenase 10, hydroxysteroid 17-beta dehydrogenase 10, hydroxysteroid (17-β) dehydrogenase 10, hydroxysteroid 17-β dehydrogenase 10, Hydroxysteroid dehydrogenase 10, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, XH98G2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsd17b10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 7alpha-hydroxysteroid dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- 3(or 17)beta-hydroxysteroid dehydrogenase
- estradiol 17beta-dehydrogenase
- enzyme
- 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
- estrogen receptor binding
- identical protein binding
- polyketide synthase keto reductase domain
- amyloid beta binding domain
- CH-OH group:NAD or NADP oxidoreductase
- steroid dehydrogenase
- tRNA binding
- mitochondrial presequence
- 3-hydroxyacyl-CoA dehydrogenase
- KR domain
- pteridine reductase
- Enoyl-(Acyl carrier protein) reductase
- protein binding
- beta-amyloid binding
- steroid binding
- NAD or NADH binding
- sepiapterin reductase
- 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD)
- acetoacetyl-CoA reductase
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Hsd17b10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mental retardation
- hereditary disorder
- uterine leiomyoma
- leiomyomatosis
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- 17-beta-hydroxysteroid dehydrogenase X deficiency
role in cell
- apoptosis
- activation in
- cell viability
- function
- consumption in
- formation in
- accumulation in
- fragmentation in
- dysfunction in
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsd17b10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- androgen metabolic process
- protein homotetramerization
- estrogen metabolic process
- lipid metabolic process
- isoleucine catabolic process
- bile acid biosynthetic process
- C21-steroid hormone metabolic process
- mitochondrial tRNA methylation
- mitochondrion organization
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- tRNA methyltransferase complex
- mitochondrial ribonuclease P complex
- mitochondrial matrix
- cytoplasm
- mitochondrion
- plasma membrane
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- estradiol 17-beta-dehydrogenase activity
- RNA binding
- protein binding
- 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
- cholate 7-alpha-dehydrogenase activity
- 3-hydroxyacyl-CoA dehydrogenase activity
- testosterone dehydrogenase (NAD+) activity
- 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
- testosterone dehydrogenase [NAD(P)] activity
- tRNA binding