Hdac5 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to fluid shear stress; positive regulation of cell population proliferation; and regulation of myotube differentiation. Acts upstream of or within several processes, including negative regulation of macromolecule biosynthetic process; negative regulation of osteoblast differentiation; and regulation of myotube differentiation. Located in several cellular components, including axonal growth cone; chromatin; and nuclear body. Part of RNA polymerase II transcription repressor complex. Is active in nucleus. Is expressed in several structures, including central nervous system; early embryo; head bone; sensory organ; and upper arm. Orthologous to human HDAC5 (histone deacetylase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdac5 |
| Official Name | histone deacetylase 5 [Source:MGI Symbol;Acc:MGI:1333784] |
| Ensembl ID | ENSMUSG00000008855 |
| Bio databases IDs | |
| Aliases | histone deacetylase 5 |
| Synonyms | HD5, Hdac4, histone deacetylase 5, mHDA1, mKIAA0600, NY-CO-9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hdac5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CtBP binding domain
- transcription regulator
- transcription co-repressor
- deacetylase motif
- transcription factor binding
- chromatin binding
- identical protein binding
- protein deacetylase activity
- ClassIIa_HDAC_Gln-rich-N
- AMPK phosphorylation site
- histone deacetylase
- Pka phosphorylation site
- CaMK phosphorylation site
- protein kinase binding
- catalytic domain
- nucleic acid binding
- protein kinase C binding
- nuclear localization sequence
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- Arginase-like and histone-like hydrolases
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Hdac5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Apelin Endothelial Signaling Pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- neoplasia
- epithelial cancer
- colon adenocarcinoma
- colon epithelial cancer
- breast carcinoma
- hypertrophic scarring
- weight loss
- hyperglycemia
- head and neck squamous cell carcinoma
role in cell
- cell viability
- apoptosis
- expression in
- phosphorylation in
- proliferation
- binding in
- invasion by
- morphology
- migration
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- axon component
- Cytoplasm
- Golgi Apparatus
- cytosol
- nuclear foci
- perinucleolar compartments
- MAD bodies
- nucleoplasm
- nuclear bodies
- nuclear rim
- nuclear speckles
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hdac5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- B cell differentiation
- neuron differentiation
- response to cocaine
- B cell activation
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- negative regulation of cell migration involved in sprouting angiogenesis
- cellular response to insulin stimulus
- negative regulation of transcription from RNA polymerase II promoter
- inflammatory response
- negative regulation of transcription, DNA-dependent
- cellular response to lipopolysaccharide
- regulation of protein binding
- regulation of myotube differentiation
- negative regulation of myotube differentiation
- response to activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- histone deacetylase complex
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- protein kinase C binding
- identical protein binding
- protein binding
- histone deacetylase binding
- histone deacetylase activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- chromatin binding
- protein deacetylase activity