Mbl2 Gene Summary [Mouse]
Predicted to enable several functions, including calcium-dependent protein binding activity; monosaccharide binding activity; and phosphatidylinositol-4-phosphate binding activity. Acts upstream of or within defense response to other organism and positive regulation of phagocytosis. Located in extracellular space. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mbl2 |
| Official Name | mannose-binding lectin (protein C) 2 [Source:MGI Symbol;Acc:MGI:96924] |
| Ensembl ID | ENSMUSG00000024863 |
| Bio databases IDs | |
| Aliases | mannose-binding lectin (protein C) 2 |
| Synonyms | Ab2-001, Ab2-011, COLEC1, HSMBPC, L-MBP, LOC100911854, MANNOSE-binding, mannose binding lectin 2, mannose-binding lectin (protein C) 2, MBL, MBL2D, MBL-C, MBP, MBP1, MBP-C, MBPD, RARF/P28A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mbl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- collagen-like domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protease binding
- calcium ion binding
- protein binding
- receptor binding
- identical protein binding
- mannose binding
- phosphatidylinositol binding
- galactose binding
- Lectin C-type domain
- Collagen triple helix repeat (20 copies)
- neck domain
Pathways
Biological processes and signaling networks where the Mbl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infection
- rheumatoid arthritis
- liver cancer
- systemic inflammatory response syndrome
- mannose-binding lectin deficiency
- organismal death
- Staphylococcus aureus pneumonia
- systemic lupus erythematosus
- epithelial cancer
regulated by
- Immunoglobulin
- Sendai virus
- mir-34 (includes others)
- TNF
- calcitriol
- lipopolysaccharide
- TP53
- Ca2+
- ethylenediaminetetraacetic acid
- Prokarilysin
role in cell
- binding
- uptake
- quantity
- growth
- proliferation
- metastatic potential
- attachment
- number
- phagocytosis by
- recognition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- endoplasmic reticulum lumen
- rough endoplasmatic reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mbl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of viral reproduction
- defense response to bacterium
- acute-phase response
- opsonization
- surfactant homeostasis
- killing by host of symbiont cells
- cell surface pattern recognition receptor signaling pathway
- response to oxidative stress
- complement activation, classical pathway
- innate immune response
- complement activation, lectin pathway
- proteolysis
- positive regulation of phagocytosis
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- external side of plasma membrane
- multivesicular body
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- mannose binding
- calcium-dependent protein binding
- receptor binding