Mlf2 Gene Summary [Mouse]
Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Is active in glutamatergic synapse. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human MLF2 (myeloid leukemia factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Mlf2 |
| Official Name | myeloid leukemia factor 2 [Source:MGI Symbol;Acc:MGI:1353554] |
| Ensembl ID | ENSMUSG00000030120 |
| Bio databases IDs | |
| Aliases | myeloid leukemia factor 2 |
| Synonyms | myeloid leukaemia factor 2, myeloid leukemia factor 2, NTN4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mlf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Myelodysplasia-myeloid leukemia factor 1-interacting protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- insomnia
- eczema
- Huntington disease
- schizophrenia
- colorectal adenocarcinoma
- colorectal carcinomagenesis
- restless legs syndrome
role in cell
- interaction in
- destabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mlf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding