Rnf31 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in CD40 signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and protein polyubiquitination. Acts upstream of or within canonical NF-kappaB signal transduction; negative regulation of canonical NF-kappaB signal transduction; and negative regulation of necroptotic process. Located in cytoplasmic side of plasma membrane and cytosol. Part of CD40 receptor complex and LUBAC complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 115. Orthologous to human RNF31 (ring finger protein 31). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf31 |
| Official Name | ring finger protein 31 [Source:MGI Symbol;Acc:MGI:1934704] |
| Ensembl ID | ENSMUSG00000047098 |
| Bio databases IDs | |
| Aliases | ring finger protein 31 |
| Synonyms | AL033293, BC031509, Flj10111, HOIP, IMD115, mFLJ00217, Paul, ring finger protein 31, ZIBRA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- NZF domain
- ubiquitin protein ligase binding
- IBR domain, a half RING-finger domain
- ubiquitin protein ligase activity
- PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
- PNGase/UBA- or UBX-containing domain
- BRcat_Rcat_RBR
- ubiquitin binding
- enzyme
- protein binding
- identical protein binding
- HOIP UBA domain pair
- B-box-type zinc finger superfamily
- Zn-finger in Ran binding protein and others
- In Between Ring fingers
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- E3 Ubiquitin Ligase RBR C-terminal domain
- ubiquitin-protein transferase activity
- PUB domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- immunodeficiency type 115 with autoinflammation
- cholangiocarcinoma cancer
- bile duct cancer
- liver neoplasia
- biliary tract cancer
- abdominal cancer
- digestive system cancer
role in cell
- survival
- phosphorylation in
- expression in
- proliferation
- activation in
- binding in
- apoptosis
- cell death
- production in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- cytoplasmic face of plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CD40 signaling pathway
- protein polyubiquitination
- protein linear polyubiquitination
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- defense response to bacterium
- T cell receptor signaling pathway
- negative regulation of necroptosis
Cellular Component
Where in the cell the gene product is active
- cytosol
- LUBAC complex
- CD40 receptor complex
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- ubiquitin binding
- K63-linked polyubiquitin binding