Cyfip1 Gene Summary [Mouse]
Enables translation repressor activity. Involved in several processes, including dendrite extension; positive regulation of neurotrophin TRK receptor signaling pathway; and regulation of modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium assembly. Located in lamellipodium; neuron projection; and perinuclear region of cytoplasm. Is active in postsynapse. Is expressed in several structures, including embryo mesenchyme; lung; nervous system; skeletal muscle; and tooth. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cyfip1 |
| Official Name | cytoplasmic FMR1 interacting protein 1 [Source:MGI Symbol;Acc:MGI:1338801] |
| Ensembl ID | ENSMUSG00000030447 |
| Bio databases IDs | |
| Aliases | cytoplasmic FMR1 interacting protein 1 |
| Synonyms | AC270230.1, cytoplasmic FMR1 interacting protein 1, E030028J09Rik, KIAA0068, l71Rl, l(7)1Rl, l7Rl1, mKIAA0068, P140SRA-1, pl-1, SHYC, SRA-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyfip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- RNA 7-methylguanosine cap binding
- translation repressor
- enzyme binding
- protein binding
- Cytoplasmic Fragile-X interacting family
- translation regulator
- profilin binding
Pathways
Biological processes and signaling networks where the Cyfip1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- atopic dermatitis
- neoplastic cell transformation
- post-traumatic stress disorder
- global developmental delay with intellectual disability
role in cell
- proliferation
- phosphorylation in
- growth
- number
- response
- phagocytosis
- activation
- turnover
- phagocytosis by
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- clathrin-coated structures
- axon component
- ruffle
- secretory granule lumen
- cell surface
- Extracellular Space
- perinuclear region
- postsynaptic region
- organelle lumens
- cytosol
- dendritic spines
- growth cone
- neurites
- synaptosomes
- filopodia
- cell membrane leading edge
- perikaryon
- dendrites
- axon terminals
- excitatory synapses
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyfip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of lamellipodium assembly
- Rac protein signal transduction
- cell morphogenesis
- axon guidance
- positive regulation of axon extension
- positive regulation of ruffle assembly
- positive regulation of dendrite development
- regulation of translation
- regulation of actin filament polymerization
- cellular response to insulin stimulus
- positive regulation of nerve growth factor receptor signaling pathway
- cognition
- axon extension
- ruffle organization
- lamellipodium assembly
- regulation of myelination
- positive regulation of Arp2/3 complex-mediated actin nucleation
- response to electrical stimulus
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- excitatory synapse
- synapse
- neuronal cell body
- extracellular region
- neuron projection
- SCAR complex
- dendritic growth cone
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- focal adhesion
- terminal button
- axonal growth cone
- dendritic spine
- ruffle
- cytosol
- filopodium tip
- secretory granule lumen
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- RNA 7-methylguanosine cap binding
- protein binding
- translation repressor activity
- small GTPase binding