Ttll3 Gene Summary [Mouse]
Enables protein-glycine ligase activity, initiating. Involved in flagellated sperm motility and protein polyglycylation. Acts upstream of or within cilium assembly. Located in axoneme; microtubule cytoskeleton; and sperm flagellum. Is expressed in midbrain ventricular layer; node; and pons ventricular layer. Orthologous to human TTLL3 (tubulin tyrosine ligase like 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttll3 |
| Official Name | tubulin tyrosine ligase-like family, member 3 [Source:MGI Symbol;Acc:MGI:2141418] |
| Ensembl ID | ENSMUSG00000030276 |
| Bio databases IDs | |
| Aliases | tubulin tyrosine ligase-like family, member 3 |
| Synonyms | 4833441J24RIK, HOTTL, LOC687148, tubulin tyrosine ligase like 3, tubulin tyrosine ligase-like family, member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttll3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acid-D-amino acid ligase
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- microtubule cytoskeleton
- cilia
- axonemes
- cytosol
- sperm tail
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttll3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyglycylation
- sperm motility
- cilium morphogenesis
- axoneme assembly
- cilium movement
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cilium
- cytosol
- sperm flagellum
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- protein-glycine ligase activity
- protein-glycine ligase activity, initiating