Cct4 Gene Summary [Mouse]
Predicted to enable protein folding chaperone and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and gut. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cct4 |
| Official Name | chaperonin containing Tcp1, subunit 4 (delta) [Source:MGI Symbol;Acc:MGI:104689] |
| Ensembl ID | ENSMUSG00000007739 |
| Bio databases IDs | |
| Aliases | chaperonin containing Tcp1, subunit 4 (delta) |
| Synonyms | 2610204B21RIK, A45, Cctd, CCT-DELTA, CCT-δ, chaperonin containing TCP1 subunit 4, SRB, T complex protein 1, delta subunit, T complex protein 1, δ subunit, TCP1 delta, TCP1 δ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cct4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein binding
- chaperonin_like
- TCP-1/cpn60 chaperonin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- invasive breast cancer
- Wilms tumor
- Wilms tumorigenesis
- infection by Influenza A virus subtype H1N1
role in cell
- apoptosis
- cell viability
- cell death
- mitosis
- trafficking
- binding
- aggregation in
- trafficking in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- centrosome
- microtubules
- cytosol
- nucleoplasm
- synaptic vesicles
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cct4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of telomerase activity
- binding of sperm to zona pellucida
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein stabilization
- protein folding
Cellular Component
Where in the cell the gene product is active
- chaperonin-containing T-complex
- centrosome
- extracellular vesicular exosome
- melanosome
- cell body
- cytosol
- cell projection
- sperm protein complex
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- protein binding involved in protein folding
- unfolded protein binding