Necap1 Gene Summary [Mouse]
Involved in endocytosis. Located in clathrin-coated pit. Part of clathrin vesicle coat. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 21. Orthologous to human NECAP1 (NECAP endocytosis associated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Necap1 |
| Official Name | NECAP endocytosis associated 1 [Source:MGI Symbol;Acc:MGI:1914852] |
| Ensembl ID | ENSMUSG00000030327 |
| Bio databases IDs | |
| Aliases | NECAP endocytosis associated 1 |
| Synonyms | 1200016B17RIK, DEE21, EIEE21, NECAP endocytosis associated 1, RGD1306053 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Necap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF1681)
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cellular membrane
- cytosol
- clathrin-coated pits
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Necap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- protein transport
- endocytosis
Cellular Component
Where in the cell the gene product is active
- coated pit
- cytosol
- clathrin vesicle coat
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding