Tmub1 Gene Summary [Mouse]
Predicted to be involved in ERAD pathway. Predicted to be located in several cellular components, including centrosome; postsynaptic membrane; and recycling endosome. Orthologous to human TMUB1 (transmembrane and ubiquitin like domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmub1 |
| Official Name | transmembrane and ubiquitin-like domain containing 1 [Source:MGI Symbol;Acc:MGI:1923764] |
| Ensembl ID | ENSMUSG00000028958 |
| Bio databases IDs | |
| Aliases | transmembrane and ubiquitin-like domain containing 1 |
| Synonyms | 2010004O20Rik, C7orf21, DULP, HOPS, SB144, transmembrane and ubiquitin-like domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmub1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- habitual abortion
- hyperactive behavior
- abortion
- organismal death
regulated by
- lipopolysaccharide
- TP53
- NPM1
role in cell
- apoptosis
- number
- phosphorylation in
- ubiquitination in
- degradation in
- inflammation in
- stabilization in
- interaction in
- polyubiquitination in
- endoplasmic reticulum-associated degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Nucleus
- endosomal membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmub1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- centrosome
- postsynaptic membrane
- recycling endosome
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding