Ap2m1 Gene Summary [Mouse]
This gene encodes the mu subunit of the clathrin adaptor protein complex AP-2. It mediates sorting of cargo proteins harboring Y-X-X-Phi motifs into clathrin-coated vesicles. Alternate splicing of this gene results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2, 8 and 19. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | Ap2m1 |
| Official Name | adaptor-related protein complex 2, mu 1 subunit [Source:MGI Symbol;Acc:MGI:1298405] |
| Ensembl ID | ENSMUSG00000022841 |
| Bio databases IDs | |
| Aliases | adaptor-related protein complex 2, mu 1 subunit |
| Synonyms | adaptor-related protein complex 2, mu 1 subunit, adaptor related protein complex 2 subunit mu 1, AP2M, AP2 mu, Ap2 Mu1, AP2 MU2, AP-2 mu2 subunit, AP50, CLAPM1, MRD60, mu2, Mu2 adaptin, Mu 2 subunit of AP-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ap2m1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- tyrosine binding pocket
- AP_MHD_Cterm
- protein binding activity, bridging
- ion channel binding
- Adaptor complexes medium subunit family
- linker domain
- protein domain specific binding
- protein binding
- low-density lipoprotein receptor binding
- Longin-like domains
- signal sequence binding
Pathways
Biological processes and signaling networks where the Ap2m1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- autosomal dominant intellectual developmental disorder with seizures type 60
- complex neurodevelopmental disorder
- infection by HIV-1
role in cell
- necrosis
- expression in
- apoptosis
- degradation in
- phosphorylation in
- migration
- accumulation in
- replication in
- downregulation in
- function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endocytic vesicle membrane
- cellular membrane
- Plasma Membrane
- cytosol
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- synapse
- secretory granules
- clathrin-coated pits
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ap2m1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- vesicle-mediated transport
- membrane budding
- macromolecular complex assembly
- positive regulation of receptor internalization
- synaptic vesicle endocytosis
- positive regulation of synaptic vesicle endocytosis
- intracellular protein transport
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- clathrin-coated endocytic vesicle
- lysosomal membrane
- plasma membrane
- internal side of plasma membrane
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- coated pit
- cytoplasmic vesicle
- cytosol
- AP-2 adaptor complex
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- low-density lipoprotein particle receptor binding
- clathrin adaptor activity
- lipid binding
- signal sequence binding
- ion channel binding