Ap1g1 Gene Summary [Mouse]
Predicted to enable several functions, including GTP-dependent protein binding activity; clathrin adaptor activity; and kinesin binding activity. Predicted to be involved in Golgi to lysosome transport; endosome to melanosome transport; and positive regulation of natural killer cell degranulation. Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Located in perinuclear region of cytoplasm and trans-Golgi network. Is active in presynapse. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human AP1G1 (adaptor related protein complex 1 subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap1g1 |
| Official Name | adaptor protein complex AP-1, gamma 1 subunit [Source:MGI Symbol;Acc:MGI:101919] |
| Ensembl ID | ENSMUSG00000031731 |
| Bio databases IDs | |
| Aliases | adaptor protein complex AP-1, gamma 1 subunit |
| Synonyms | Adaptin gamma, Adaptin γ, adaptor protein complex AP-1, gamma 1 subunit, adaptor protein complex AP-1, γ 1 subunit, adaptor related protein complex 1 subunit gamma 1, adaptor related protein complex 1 subunit γ 1, ADTG, AU041323, CLAPG1, D8Ertd374e, USRISD, γ-adaptin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ap1g1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- appendage domain
- GTP-dependent protein binding
- clathrin binding domain
- ear domain
- Adaptin C-terminal domain
- hinge domain
- enzyme binding
- collagen binding
- protein binding
- Adaptin N terminal region
- kinesin binding
Pathways
Biological processes and signaling networks where the Ap1g1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- complex neurodevelopmental disorder
- autosomal dominant Usmani-Riazuddin syndrome
- autosomal recessive Usmani-Riazzudin syndrome
- growth failure
- hereditary disorder
- schizophrenia
- aortic valve calcification
- weight gain
- neurodevelopmental disorder
- Hutchinson-Gilford progeria syndrome
role in cell
- growth
- number
- cytotoxicity
- retention in
- endocytosis
- function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- presynaptic regions
- Golgi region
- perinuclear region
- cellular membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans face of the Golgi apparatus
- trans Golgi network
- lysosome membrane
- perinuclear space
- recycling endosomes
- Golgi vesicles
- clathrin-coated vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ap1g1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- platelet dense granule organization
- melanosome organization
- vesicle-mediated transport
- synaptic vesicle budding from endosome
- synaptic vesicle endocytosis
- endosome to melanosome transport
- positive regulation of natural killer cell degranulation
- intracellular protein transport
- Golgi to lysosome transport
- positive regulation of natural killer cell mediated cytotoxicity
- Golgi to vacuole transport
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
- lysosomal membrane
- early endosome
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- cytoplasm
- coated pit
- intracellular membrane-bounded organelle
- membrane
- AP-1 adaptor complex
- cytosol
- recycling endosome
- clathrin-coated vesicle
- trans-Golgi network membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding
- kinesin binding
- small GTPase binding
- clathrin adaptor activity
- GTP-dependent protein binding