Tmc5 Gene Summary [Mouse]
Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be located in plasma membrane. Is expressed in sensory organ and skeleton. Orthologous to human TMC5 (transmembrane channel like 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmc5 |
| Official Name | transmembrane channel-like gene family 5 [Source:MGI Symbol;Acc:MGI:1921674] |
| Ensembl ID | ENSMUSG00000030650 |
| Bio databases IDs | |
| Aliases | transmembrane channel-like gene family 5 |
| Synonyms | 4932443L08Rik, LOC102724257, SAYY8238, transmembrane channel-like 5, transmembrane channel-like gene family 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated chloride channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- mechanically-gated ion channel activity