Dnhd1 Gene Summary [Mouse]
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sperm flagellum assembly. Located in sperm flagellum. Is expressed in cartilage; central nervous system; genitourinary system; stomach; and trachea. Human ortholog(s) of this gene implicated in spermatogenic failure 65. Orthologous to human DNHD1 (dynein heavy chain domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnhd1 |
| Official Name | dynein heavy chain domain 1 [Source:MGI Symbol;Acc:MGI:1924755] |
| Ensembl ID | ENSMUSG00000030882 |
| Bio databases IDs | |
| Aliases | dynein heavy chain domain 1 |
| Synonyms | 8030491N06Rik, C11orf47, CCDC35, DHCD1, DNHD1L, Dnhd1-ps1, dynein heavy chain domain 1, Gm9571, LOC283293, LOC675570, LOC686729, LOC690093, SPGF65 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnhd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- P-loop containing dynein motor region D4
- Dynein heavy chain, N-terminal region 2
- Dynein heavy chain AAA lid domain
- Dynein heavy chain C-terminal domain
- ATP-binding dynein motor region
- Dynein heavy chain region D6 P-loop domain
- Hydrolytic ATP binding site of dynein motor region
- Microtubule-binding stalk of dynein motor
- P-loop containing dynein motor region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnhd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
Cellular Component
Where in the cell the gene product is active
- inner dynein arm
- extracellular vesicular exosome
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- ATP binding
- dynein light intermediate chain binding
- minus-end-directed microtubule motor activity
- dynein intermediate chain binding