Kcna3 Gene Summary [Mouse]
Enables voltage-gated potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in axon and plasma membrane. Is expressed in brain and heart. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcna3 |
| Official Name | potassium voltage-gated channel, shaker-related subfamily, member 3 [Source:MGI Symbol;Acc:MGI:96660] |
| Ensembl ID | ENSMUSG00000047959 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, shaker-related subfamily, member 3 |
| Synonyms | HGK5, HLK3, HPCN3, HUKIII, Kca1-3, KV1.3, KV1.3 alpha subunit, KV1.3 α subunit, MK3, PCN3, POTASSIUM VOLTAGE-GATED CHANNEL SHAKER-RELATED 3, potassium voltage-gated channel, shaker-related subfamily, member 3, potassium voltage-gated channel subfamily A member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcna3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- outward rectifier potassium channel
- delayed rectifier potassium channel
- Ion transport protein
- BTB_POZ
- protein binding
- pore domain
- ion channel
- voltage-gated potassium channel
- subregion I of the P region
- Broad-Complex, Tramtrack and Bric a brac
- transmembrane domain
- cytosolic tail domain
- voltage-gated ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- obesity
- multiple sclerosis
- nonarteritic ischemic optic neuropathy
- tumorigenesis
- Alzheimer disease
- secondary progressive multiple sclerosis
- nerve injury
- diabetic nephropathy
- primary progressive multiple sclerosis
role in cell
- binding in
- expression in
- activation in
- apoptosis
- phosphorylation in
- proliferation
- differentiation
- size
- morphology
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- immunological synapses
- cytosol
- endoplasmic reticulum membrane
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- mitochondrial membrane
- membrane rafts
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcna3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- protein homooligomerization
- regulation of action potential
- corpus callosum development
- optic nerve development
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic membrane
- voltage-gated potassium channel complex
- membrane raft
- membrane
- plasma membrane
- axon
- calyx of Held
Molecular Function
What the gene product does at the molecular level
- protein binding
- delayed rectifier potassium channel activity
- outward rectifier potassium channel activity
- voltage-gated ion channel activity