Gabrq Gene Summary [Mouse]
Predicted to enable GABA-A receptor activity and GABA-gated chloride ion channel activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to act upstream of or within chloride transport and gamma-aminobutyric acid signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of GABA-A receptor complex. Is expressed in several structures, including brain; eye; genitourinary system; immune system; and liver and biliary system. Orthologous to human GABRQ (gamma-aminobutyric acid type A receptor subunit theta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabrq |
| Official Name | gamma-aminobutyric acid (GABA) A receptor, subunit theta [Source:MGI Symbol;Acc:MGI:1888498] |
| Ensembl ID | ENSMUSG00000031344 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid (GABA) A receptor, subunit theta |
| Synonyms | gamma-aminobutyric acid type A receptor subunit theta, THETA, γ-aminobutyric acid type A receptor subunit θ, θ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabrq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- neurotransmitter transporter
- protein binding
- extracellular ligand-gated ion channel
- ion channel
- anion channel
- LGIC_ECD
- neurotransmitter receptor
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- ligand-gated ion channel
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Gabrq gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- postoperative pain
- HIV infection
- fatigue
- relapsing-remitting multiple sclerosis
- critical illness
- non-small cell lung cancer
- breast cancer
- upper motor neuron disease
- alcohol withdrawal syndrome
regulates
- chloride
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabrq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurotransmitter transport
- regulation of membrane potential
- signal transduction
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- postsynaptic membrane
- receptor complex
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neurotransmitter transporter activity
- protein binding
- transmembrane signaling receptor activity
- neurotransmitter receptor activity
- GABA-A receptor activity
- chloride channel activity
- GABA-gated chloride ion channel activity