Gnmt Gene Summary [Mouse]
Enables glycine N-methyltransferase activity and glycine binding activity. Involved in S-adenosylmethionine metabolic process and protein homotetramerization. Acts upstream of or within several processes, including glycogen metabolic process; one-carbon metabolic process; and regulation of gluconeogenesis. Predicted to be part of methyltransferase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; limb; sensory organ; and skeleton. Used to study glycine N-methyltransferase deficiency and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Gnmt |
| Official Name | glycine N-methyltransferase [Source:MGI Symbol;Acc:MGI:1202304] |
| Ensembl ID | ENSMUSG00000002769 |
| Bio databases IDs | |
| Aliases | glycine N-methyltransferase |
| Synonyms | glycine N-methyltransferase, HEL-S-182mP, LOC100911564 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnmt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- glycine N-methyltransferase
- binding protein
- folic acid binding
- glycine binding
- enzyme
- protein binding
- AdoMet_MTases
- methyltransferase domain
- S-adenosylmethionine-dependent methyltransferase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- diabetes mellitus
- abdominal cancer
- epithelial cancer
- epithelial neoplasia
- benign neoplasia
- hepatic steatosis
- steatohepatitis
- hepatocellular carcinoma
- liver cancer
role in cell
- proliferation
- accumulation in
- apoptosis
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnmt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein homotetramerization
- glycogen metabolic process
- S-adenosylhomocysteine metabolic process
- regulation of gluconeogenesis
- S-adenosylmethionine metabolic process
- one-carbon metabolic process
- methionine metabolic process
- methylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- glycine N-methyltransferase activity
- glycine binding
- folic acid binding