Arhgap6 Gene Summary [Mouse]
Enables GTPase activator activity. Involved in positive regulation of GTPase activity. Acts upstream of or within actin filament organization and focal adhesion assembly. Located in actin cytoskeleton. Is expressed in lower leg bone. Used to study microphthalmia. Orthologous to human ARHGAP6 (Rho GTPase activating protein 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap6 |
| Official Name | Rho GTPase activating protein 6 [Source:MGI Symbol;Acc:MGI:1196332] |
| Ensembl ID | ENSMUSG00000031355 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 6 |
| Synonyms | RHOGAP6, RHOGAPX-1, Rho GTPase activating protein 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- enzyme binding
- GTPase activator
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- phospholipase activator
Pathways
Biological processes and signaling networks where the Arhgap6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- cytosol
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of focal adhesion assembly
- negative regulation of stress fiber assembly
- regulation of small GTPase mediated signal transduction
- actin filament polymerization
- Rho protein signal transduction
- focal adhesion assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- actin cytoskeleton
- cytosol
- actin filament
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- phospholipase binding
- SH3 domain binding
- phospholipase activator activity