Chrna6 Gene Summary [Mouse]
Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in behavioral response to nicotine and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within membrane depolarization and regulation of dopamine secretion. Part of acetylcholine-gated channel complex. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in alcohol use disorder; cocaine abuse; and nicotine dependence. Orthologous to human CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrna6 |
| Official Name | cholinergic receptor, nicotinic, alpha polypeptide 6 [Source:MGI Symbol;Acc:MGI:106213] |
| Ensembl ID | ENSMUSG00000031491 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, nicotinic, alpha polypeptide 6 |
| Synonyms | Acra6, alpha6 NACHR, CHNRA6, cholinergic receptor nicotinic alpha 6 subunit, cholinergic receptor, nicotinic, alpha polypeptide 6, cholinergic receptor nicotinic α 6 subunit, cholinergic receptor, nicotinic, α polypeptide 6, Nica6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrna6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- acetylcholine receptor
- neurotransmitter receptor
- binding protein
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Chrna6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- coronary disease
- nicotine dependence
- nicotine withdrawal syndrome
- coma
- tobacco dependence
- alcoholism
- HIV infection
- psychological disorder
- myoclonus
regulates
- dopamine
- nicotine
- epibatidine
- cytisine
role in cell
- depolarization
- binding
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrna6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dopamine secretion
- synaptic transmission, cholinergic
- regulation of excitatory postsynaptic membrane potential
- signal transduction
- ion transmembrane transport
- synaptic transmission
- response to nicotine
- membrane depolarization
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic membrane
- acetylcholine-gated channel complex
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylcholine receptor activity
- acetylcholine-gated cation channel activity