Wrn Gene Summary [Mouse]
Enables 3'-5' exonuclease activity. Involved in DNA geometric change and DNA replication. Acts upstream of or within several processes, including determination of adult lifespan; regulation of growth rate; and replicative senescence. Located in chromosome, telomeric region; nucleoplasm; and replication fork. Is expressed in coelomic epithelium of testis; metanephros; and spleen. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wrn |
| Official Name | Werner syndrome RecQ like helicase [Source:MGI Symbol;Acc:MGI:109635] |
| Ensembl ID | ENSMUSG00000031583 |
| Bio databases IDs | |
| Aliases | Werner syndrome RecQ like helicase |
| Synonyms | RECQ3, RECQL2, RECQL3, RGD1564788, Werner syndrome RecQ like helicase, WRN RecQ like helicase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wrn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein interaction domain
- protein repeat
- Helicase and RNase D C-terminal
- 3'-5' exonuclease
- ATP-dependent DNA helicase, RecQ family
- DNA secondary structure binding
- transcription activation domain
- Ku binding domain
- chromatin binding
- enzyme
- helix-turn-helix domain
- holliday junction helicase
- ATPase
- Helicase conserved C-terminal domain
- RQC domain
- telomeric DNA binding
- DNA helicase
- helicase domain
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- Type III restriction enzyme, res subunit
- RecQ zinc-binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- nucleolar targeting motif
- p53-binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ser/Thr-Gln motif
- HRDC domain
- oligomerization domain
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- recq conserved domain
- PRK11057
- protein binding
- magnesium ion binding
- acidic domain
- DNA binding
- binding protein
- damaged DNA binding
- RQC
- protein homodimerization
- ATP-dependent DNA helicase RecQ
- manganese ion binding
- exonuclease domain
Pathways
Biological processes and signaling networks where the Wrn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial neoplasia
- benign neoplasia
- infection
- Werner syndrome
- cardiac fibrosis
- head and neck neoplasia
- metabolic syndrome X
- renal clear cell adenocarcinoma
role in cell
- proliferation
- expression in
- cell viability
- cell death
- apoptosis
- survival
- phosphorylation in
- infiltration by
- growth
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- nuclear matrix fraction
- nucleolar fraction
- nucleolar region
- centrosome
- granules
- nuclear foci
- nucleoplasm
- nucleolus derived foci
- nucleoli
- nuclear speckles
- telomeres
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wrn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair
- replicative senescence
- determination of adult lifespan
- DNA replication
- cellular senescence
- double-strand break repair via homologous recombination
- telomere maintenance
- cellular response to starvation
- DNA metabolic process
- DNA synthesis involved in DNA repair
- response to DNA damage stimulus
- regulation of growth rate
- DNA unwinding involved in replication
- double-strand break repair
- positive regulation of hydrolase activity
- response to oxidative stress
- cellular response to gamma radiation
- DNA duplex unwinding
- telomere maintenance via semi-conservative replication
- response to UV-C
- replication fork processing
Cellular Component
Where in the cell the gene product is active
- replication fork
- chromosome, telomeric region
- nucleus
- centrosome
- cytoplasm
- nuclear speck
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein homodimerization activity
- bubble DNA binding
- four-way junction helicase activity
- Y-form DNA binding
- chromatin binding
- 3'-5' DNA helicase activity
- four-way junction DNA binding
- magnesium ion binding
- DNA binding
- ATP binding
- 3'-5' exonuclease activity
- DNA helicase activity
- MutLalpha complex binding
- protein binding
- G-quadruplex DNA binding
- exonuclease activity
- manganese ion binding
- 3'-flap-structured DNA binding
- isomerase activity