Skap1 Gene Summary [Mouse]
Predicted to enable SH2 domain binding activity; protein kinase binding activity; and protein phosphatase binding activity. Acts upstream of or within positive regulation of cell adhesion and protein localization to plasma membrane. Located in cell-cell junction; cytosol; and plasma membrane. Part of T cell receptor complex. Orthologous to human SKAP1 (src kinase associated phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Skap1 |
| Official Name | src family associated phosphoprotein 1 [Source:MGI Symbol;Acc:MGI:1925723] |
| Ensembl ID | ENSMUSG00000057058 |
| Bio databases IDs | |
| Aliases | src family associated phosphoprotein 1 |
| Synonyms | 1700091G21Rik, HEL-S-81p, SCAP1, SKAP55, src family associated phosphoprotein 1, src kinase associated phosphoprotein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Skap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- binding protein
- protein kinase binding
- SH2-domain binding
- protein phosphatase binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- SH3-domain binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Skap1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- schizophrenia
- prostate cancer
- gastric cancer
- esophageal carcinoma formation
- organismal death
- chronic fatigue syndrome
- ovarian carcinoma
- epithelial ovarian cancer
- keratoconus
role in cell
- binding in
- expression in
- proliferation
- phosphorylation in
- migration
- development
- adhesion
- invasion by
- interaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular compartment
- intracellular space
- cellular membrane
- Plasma Membrane
- intercellular junctions
- immunological synapses
- cytosol
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Skap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of adaptive immune response
- positive regulation of transcription, DNA-dependent
- positive regulation of cell-matrix adhesion
- positive regulation of heterotypic cell-cell adhesion
- adaptive immune response
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of integrin activation
- positive regulation of cell-cell adhesion mediated by integrin
- T cell receptor signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoplasm
- cytosol
- T cell receptor complex
- plasma membrane
- immunological synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein phosphatase binding
- protein binding
- SH3 domain binding
- SH2 domain binding