Neil1 Gene Summary [Mouse]
Enables DNA N-glycosylase activity and lyase activity. Acts upstream of or within DNA repair. Located in nucleus. Is expressed in ductus deferens; embryo; epididymis; and metanephros. Used to study abdominal obesity-metabolic syndrome and obesity. Orthologous to human NEIL1 (nei like DNA glycosylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neil1 |
| Official Name | nei endonuclease VIII-like 1 (E. coli) [Source:MGI Symbol;Acc:MGI:1920024] |
| Ensembl ID | ENSMUSG00000032298 |
| Bio databases IDs | |
| Aliases | nei endonuclease VIII-like 1 (E. coli) |
| Synonyms | 2810450N13Rik, FPG1, hFPG1, NEH1, NEI1, nei endonuclease VIII-like 1 (E. coli), nei-like DNA glycosylase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Neil1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA N-glycosylase
- lyase
- glycosylase
- DNA-(apurinic or apyrimidinic site) lyase
- enzyme
- protein binding
- Fpg/Nei N-terminal protein domain
- Formamidopyrimidine-DNA glycosylase N-terminal domain
- Endonuclease VIII-like 1, DNA bind
Pathways
Biological processes and signaling networks where the Neil1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- stroke
- gastric cancer
- hepatic steatosis
- obesity
- head and neck squamous cell cancer
- adenomatous polyposis
- ulceration
- osteoarthritis
- infertility condition
role in cell
- survival
- proliferation
- repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Neil1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- base-excision repair
- negative regulation of nuclease activity
- base-excision repair, gap-filling
- depyrimidination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- DNA N-glycosylase activity
- DNA-(apurinic or apyrimidinic site) lyase activity
- damaged DNA binding
- hydrolase activity, acting on glycosyl bonds