Bcr Gene Summary [Mouse]
Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; negative regulation of metabolic process; and regulation of vesicle-mediated transport. Located in cytosol; plasma membrane; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; forelimb bud; genitourinary system; and spleen. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcr |
| Official Name | BCR activator of RhoGEF and GTPase [Source:MGI Symbol;Acc:MGI:88141] |
| Ensembl ID | ENSMUSG00000009681 |
| Bio databases IDs | |
| Aliases | BCR activator of RhoGEF and GTPase |
| Synonyms | 5133400C09Rik, AI561783, ALL, BCR1, BCR activator of RhoGEF and GTPase, CML, D22S11, D22S662, mKIAA3017, p160Bcr, PHL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- protein serine/threonine kinase
- coiled-coil domain
- GTPase activator
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- protein-tyrosine kinase
- proline rich domain
- Grb2 binding domain
- Dbl homology domain
- C2 domain
- Bcr-Abl oncoprotein oligomerization domain
- GRB2 adaptor binding domain
- tetramerization domain
- oligomerization domain
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- kinase
- RhoGEF
- guanyl-nucleotide exchange factor
- transmembrane domain
- Protein kinase C conserved region 2 (CalB)
Pathways
Biological processes and signaling networks where the Bcr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- chronic myeloid leukemia
- Parkinson disease
- dermatological disorder
- leukemogenesis
- edema
- hyperactive behavior
- acute myeloid leukemia
- Philadelphia-positive acute lymphoblastic leukemia
- T-cell leukemia
role in cell
- cell death
- signaling in
- apoptosis
- proliferation
- activation in
- expression in
- phosphorylation in
- tyrosine phosphorylation in
- quantity
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- organelle
- cell surface
- Plasma Membrane
- microtubules
- granules
- cytosol
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- negative regulation of respiratory burst
- protein phosphorylation
- renal system process
- regulation of cell cycle
- focal adhesion assembly
- negative regulation of reactive oxygen species metabolic process
- signal transduction
- small GTPase mediated signal transduction
- negative regulation of inflammatory response
- intracellular protein transmembrane transport
- neutrophil degranulation
- regulation of vascular permeability
- brain development
- negative regulation of cellular extravasation
- negative regulation of neutrophil degranulation
- negative regulation of blood vessel remodeling
- definitive hemopoiesis
- keratinocyte differentiation
- cellular response to lipopolysaccharide
- regulation of small GTPase mediated signal transduction
- homeostasis of number of cells
- inner ear morphogenesis
- phagocytosis
- regulation of synaptic transmission
- positive regulation of phagocytosis
- actin cytoskeleton organization
- neuromuscular process controlling balance
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular vesicular exosome
- membrane
- dendritic spine
- cytosol
- macromolecular complex
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- protein serine/threonine kinase activity