Frg1 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Predicted to be involved in RNA processing and muscle organ development. Predicted to be located in Cajal body and Z disc. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleolus and striated muscle dense body. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; genitourinary system; liver; and spleen. Orthologous to human FRG1 (FSHD region gene 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frg1 |
| Official Name | FSHD region gene 1 [Source:MGI Symbol;Acc:MGI:893597] |
| Ensembl ID | ENSMUSG00000031590 |
| Bio databases IDs | |
| Aliases | FSHD region gene 1 |
| Synonyms | FRG1A, FSG1, FSHD region gene 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Frg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- fascin-like domain, beta-trefoil fold, found in the fascin-like family
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- nuclear speckles
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Frg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- rRNA processing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- Z disc
- catalytic step 2 spliceosome
- striated muscle dense body
- Cajal body
- nucleolus
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- RNA binding
- protein binding