Pdgfrl Gene Summary [Mouse]
Predicted to be located in extracellular region. Is expressed in several structures, including facial prominence; physiological umbilical hernia; reproductive system; rib; and skeletal musculature. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human PDGFRL (platelet derived growth factor receptor like). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pdgfrl |
| Official Name | platelet-derived growth factor receptor-like [Source:MGI Symbol;Acc:MGI:1916047] |
| Ensembl ID | ENSMUSG00000031595 |
| Bio databases IDs | |
| Aliases | platelet-derived growth factor receptor-like |
| Synonyms | 1110039P19Rik, Pdgfr β like, PDGRL, platelet-derived growth factor receptor-like, PRLTS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdgfrl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- immunoglobulin domain
- Immunoglobulin like
- platelet activating factor receptor
- Immunoglobulin I-set domain
- platelet-derived growth factor receptor beta
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- epithelial neoplasia
- epithelial cancer
- cancer
- osteoarthritis
- liver cancer
- digestive system cancer
- abdominal cancer
- hepatocellular carcinoma
- colon cancer
regulates
- LATS
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdgfrl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- platelet-derived growth factor receptor-beta signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- platelet-derived growth factor beta-receptor activity
- platelet activating factor receptor activity