Map2k1 Gene Summary [Mouse]
Enables MAP kinase kinase activity and protein serine/threonine kinase activity. Involved in MAPK cascade; cell surface receptor protein tyrosine kinase signaling pathway; and nervous system development. Acts upstream of with a positive effect on type B pancreatic cell proliferation. Acts upstream of or within several processes, including central nervous system development; regulation of neuron projection development; and respiratory system development. Predicted to be located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Predicted to be active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and sensory organ. Used to study cardiofaciocutaneous syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map2k1 |
| Official Name | mitogen-activated protein kinase kinase 1 [Source:MGI Symbol;Acc:MGI:1346866] |
| Ensembl ID | ENSMUSG00000004936 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase 1 |
| Synonyms | CFC3, MAPKK1, Mek, MEK1, MEKK1, MEL, mitogen-activated protein kinase kinase 1, MKK1, Mkp1, MP2K1, PRKMK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map2k1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation lip domain
- protein serine/threonine kinase
- protein kinase
- protein threonine/tyrosine kinase
- ATP binding
- Protein kinase domain
- cleavage site
- proline rich domain
- fxfp sequence
- docking domain
- alcohol group acceptor phosphotransferase
- LF interacting region
- Tyrosine kinase, catalytic domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- nuclear export signal
- catalytic domain
- MAPK binding site
- nuclear localization sequence
- enzyme binding
- protein binding
- phosphorylation site
- MAP-kinase scaffold protein
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- MAP kinase kinase
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- ERK2 binding domain
Pathways
Biological processes and signaling networks where the Map2k1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- BER pathway
- Cancer Drug Resistance By Drug Efflux
- CD27 Signaling in Lymphocytes
- Chemokine Signaling
- CNTF Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- EGF Signaling
- ErbB4 Signaling
- GDNF Family Ligand-Receptor Interactions
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- Gαs Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IGF-1 Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- Prostate Cancer Signaling
- Rac Signaling
- RANK Signaling in Osteoclasts
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- stage IV melanoma
- cutaneous melanoma
- stage III melanoma
- metastasis
- squamous cell lung cancer
- metastatic non-squamous non-small cell lung cancer
- gastroesophageal junction adenocarcinoma
- esophageal adenocarcinoma
- metastatic esophageal adenocarcinoma
- colorectal neoplasia
role in cell
- apoptosis
- colony formation
- cell viability
- synthesis in
- survival
- cytotoxicity
- migration
- expression in
- activation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- early endosomal fractions
- caveolae fraction
- membrane fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- perinuclear region
- focal adhesions
- cell cortex
- Nucleus
- Plasma Membrane
- basal bodies
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- midbody
- cytosol
- spindle fibers
- early endosomes
- late endosomes
- polar microtubule
- astral microtubules
- central spindle
- mitotic spindle
- perikaryon
- axons
- dendrites
- postsynaptic density
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map2k1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- trachea formation
- Schwann cell development
- negative regulation of cell proliferation
- Bergmann glial cell differentiation
- ERBB2-ERBB3 signaling pathway
- cellular senescence
- regulation of axon regeneration
- myelination
- face development
- epithelial cell proliferation involved in lung morphogenesis
- cerebellar cortex formation
- regulation of Golgi inheritance
- thymus development
- MAPK cascade
- heart development
- chemotaxis
- positive regulation of axonogenesis
- positive regulation of transcription, DNA-dependent
- type B pancreatic cell proliferation
- placenta blood vessel development
- signal transduction
- neuron differentiation
- insulin-like growth factor receptor signaling pathway
- labyrinthine layer development
- cell motility
- ERK1 and ERK2 cascade
- keratinocyte differentiation
- thyroid gland development
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- endodermal cell differentiation
- regulation of stress-activated MAPK cascade
- positive regulation of protein serine/threonine kinase activity
- regulation of early endosome to late endosome transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- early endosome
- focal adhesion
- mitochondrion
- late endosome
- cytosol
- Golgi apparatus
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- scaffold protein binding
- protein tyrosine kinase activity
- protein serine/threonine kinase activator activity
- protein serine/threonine/tyrosine kinase activity
- protein binding
- protein kinase activator activity
- MAP kinase kinase activity
- protein kinase activity
- MAP-kinase scaffold activity
- protein serine/threonine kinase activity