Afg3l1 Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity; membrane protein dislocase activity; and metalloendopeptidase activity. Involved in protein processing. Acts upstream of or within cristae formation; mitochondrial fusion; and mitochondrial protein processing. Located in mitochondrial inner membrane. Part of m-AAA complex. Orthologous to human AFG3L1P (AFG3 like matrix AAA peptidase subunit 1, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Afg3l1 |
| Official Name | AFG3-like AAA ATPase 1 [Source:MGI Symbol;Acc:MGI:1928277] |
| Ensembl ID | ENSMUSG00000031967 |
| Bio databases IDs | |
| Aliases | AFG3-like AAA ATPase 1 |
| Synonyms | 1700047G05Rik, 3110061K15Rik, AFG3 (ATPase family gene 3)-like 1, AFG3-like AAA ATPase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Afg3l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- Peptidase family M41
- protein binding
- AAA+ lid domain
- ATPase
- AAA domain
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- ATP-dependent metalloprotease FtsH
- FtsH Extracellular
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- transporter
- metalloendopeptidase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane