Spg7 Gene Summary [Mouse]
Predicted to enable metalloendopeptidase activity. Acts upstream of or within anterograde axonal transport and mitochondrion organization. Located in mitochondrial inner membrane. Part of m-AAA complex. Is expressed in central nervous system; liver; olfactory epithelium; and retina nuclear layer. Used to study hereditary spastic paraplegia 7. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spg7 |
| Official Name | SPG7, paraplegin matrix AAA peptidase subunit [Source:MGI Symbol;Acc:MGI:2385906] |
| Ensembl ID | ENSMUSG00000000738 |
| Bio databases IDs | |
| Aliases | SPG7, paraplegin matrix AAA peptidase subunit |
| Synonyms | AI452278, AU015315, CAR, CMAR, LOC100506268, LOC100507877, PGN, SPG5C, SPG7 matrix AAA peptidase subunit, paraplegin, SPG7, paraplegin matrix AAA peptidase subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spg7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- peptidase
- Peptidase family M41
- protein binding
- ATP-dependent metalloprotease FtsH
- AAA+ lid domain
- FtsH Extracellular
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- non-insulin-dependent diabetes mellitus
- infection by HIV-1
- cutaneous melanoma
- hereditary disorder
- hereditary spastic paraplegia autosomal recessive 7
- hereditary spastic paraplegia
- melanoma
- melanoma cancer
- scoliosis
role in cell
- degeneration
- expression in
- calcium retention capacity
- adhesion
- abnormal morphology
- organization
- permeability
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial envelope
- Endoplasmic Reticulum
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spg7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- anterograde axon cargo transport
- proteolysis
- nervous system development
- mitochondrial protein processing
- regulation of mitochondrial membrane permeability
Cellular Component
Where in the cell the gene product is active
- m-AAA complex
- mitochondrial permeability transition pore complex
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- zinc ion binding
- protein binding
- unfolded protein binding
- ATP-dependent peptidase activity
- peptidase activity
- metalloendopeptidase activity