Foxl2 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear estrogen receptor binding activity. Acts upstream of or within several processes, including positive regulation of gonadotropin secretion; regulation of transcription by RNA polymerase II; and reproductive structure development. Located in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; eye; pituitary gland; and reproductive system. Used to study blepharophimosis, ptosis, and epicanthus inversus syndrome. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome; lung non-small cell carcinoma; and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxl2 |
| Official Name | forkhead box L2 [Source:MGI Symbol;Acc:MGI:1349428] |
| Ensembl ID | ENSMUSG00000050397 |
| Bio databases IDs | |
| Aliases | forkhead box L2 |
| Synonyms | AU045128, BPES, BPES1, forkhead box L2, PFRK, PINTO, POF3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- caspase regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- FH_FOX
- nucleic acid binding
- enzyme binding
- estrogen receptor binding
- protein binding
- sequence-specific DNA binding
- polyalanine repeat
- DNA binding
- FORKHEAD
- Forkhead domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- blepharophimosis, epicanthus inversus, and ptosis
- type 1 blepharophimosis, epicanthus inversus, and ptosis
- ovarian granulosa cell tumor
- ovarian neoplasia
- type 2 blepharophimosis, epicanthus inversus, and ptosis
- androgenic alopecia
- blepharophimosis, ptosis, and epicanthus inversus type II with Duane retraction syndrome
- familial premature ovarian failure
- neoplasia
- oral squamous cell carcinoma
role in cell
- cell death
- expression in
- proliferation
- migration
- activation in
- apoptosis
- differentiation
- adhesion
- development
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Flemming body
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- granulosa cell differentiation
- uterus development
- extraocular skeletal muscle development
- anatomical structure morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- single fertilization
- ovarian follicle development
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- oocyte growth
- negative regulation of transcription, DNA-dependent
- embryonic eye morphogenesis
- positive regulation of transcription, DNA-dependent
- apoptotic DNA fragmentation
- positive regulation of follicle-stimulating hormone secretion
- positive regulation of apoptotic process
- cell differentiation
- female somatic sex determination
- positive regulation of luteinizing hormone secretion
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ubiquitin conjugating enzyme binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- estrogen receptor binding
- cysteine-type endopeptidase regulator activity involved in apoptotic process
- sequence-specific DNA binding RNA polymerase II transcription factor activity