Rexo2 Gene Summary [Mouse]
Predicted to enable 3'-5'-DNA exonuclease activity; 3'-5'-RNA exonuclease activity; and magnesium ion binding activity. Predicted to be involved in DNA metabolic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human REXO2 (RNA exonuclease 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rexo2 |
| Official Name | RNA exonuclease 2 [Source:MGI Symbol;Acc:MGI:1888981] |
| Ensembl ID | ENSMUSG00000032026 |
| Bio databases IDs | |
| Aliases | RNA exonuclease 2 |
| Synonyms | 1810038D15Rik, CGI-114, REX2, RFN, RNA exonuclease 2, SFN, Smfn |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rexo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- 3'-5' exonuclease
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- EXOIII
- enzyme
- magnesium ion binding
- 3'-5' exodeoxyribonuclease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Nucleus
- Mitochondria
- mitochondrial matrix
- mitochondrial intermembrane space
- nucleoli
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rexo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA metabolic process
- nucleobase-containing compound metabolic process
- nucleotide metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- focal adhesion
- mitochondrial matrix
- cytoplasm
- mitochondrion
- nucleolus
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- magnesium ion binding
- 3'-5' exonuclease activity
- 3'-5'-exoribonuclease activity
- 3'-5'-exodeoxyribonuclease activity