REXO2 Gene Summary [Human]
This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
Details
| Type | Retained Intron |
| Official Symbol | REXO2 |
| Official Name | RNA exonuclease 2 [Source:HGNC Symbol;Acc:HGNC:17851] |
| Ensembl ID | ENSG00000076043 |
| Bio databases IDs | |
| Aliases | RNA exonuclease 2 |
| Synonyms | 1810038D15Rik, CGI-114, REX2, RFN, RNA exonuclease 2, SFN, Smfn |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human REXO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- 3'-5' exonuclease
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- EXOIII
- enzyme
- magnesium ion binding
- 3'-5' exodeoxyribonuclease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Nucleus
- Mitochondria
- mitochondrial matrix
- mitochondrial intermembrane space
- nucleoli
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human REXO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA metabolic process
- nucleobase-containing compound metabolic process
- nucleotide metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- focal adhesion
- mitochondrial matrix
- cytoplasm
- mitochondrion
- nucleolus
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- magnesium ion binding
- 3'-5' exonuclease activity
- 3'-5'-exoribonuclease activity
- 3'-5'-exodeoxyribonuclease activity