Mpg Gene Summary [Mouse]
Enables alkylbase DNA N-glycosylase activity. Acts upstream of or within base-excision repair. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; musculature; and placenta. Orthologous to human MPG (N-methylpurine DNA glycosylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mpg |
| Official Name | N-methylpurine-DNA glycosylase [Source:MGI Symbol;Acc:MGI:97073] |
| Ensembl ID | ENSMUSG00000020287 |
| Bio databases IDs | |
| Aliases | N-methylpurine-DNA glycosylase |
| Synonyms | 3-MEADE DNA GLYCOSYLASE, 9830006D05, AAG, ADPG, anpg, APNG, CRA36.1, MADG, MDG, Mid1, N-methylpurine-DNA glycosylase, PIG11, PIG16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mpg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA N-glycosylase
- DNA-3-methyladenine glycosylase II
- Methylpurine-DNA glycosylase (MPG)
- Carboxy-terminal domain of Formyltransferase and similar domains
- damaged DNA binding
- enzyme
- protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the Mpg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insulin-dependent diabetes mellitus
role in cell
- survival
- apoptosis
- quantity
- cell viability
- cell death
- number
- S phase
- cytotoxic reaction
- mutation in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mpg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA dealkylation involved in DNA repair
- base-excision repair
- depurination
Cellular Component
Where in the cell the gene product is active
- cytosol
- mitochondrial nucleoid
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- DNA-3-methyladenine glycosylase activity
- DNA-7-methylguanine glycosylase activity
- alkylbase DNA N-glycosylase activity
- DNA N-glycosylase activity
- damaged DNA binding
- DNA-7-methyladenine glycosylase activity
- DNA-3-methylguanine glycosylase activity