Barx2 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including cartilage condensation; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and skin. Orthologous to human BARX2 (BARX homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Barx2 |
| Official Name | BarH-like homeobox 2 [Source:MGI Symbol;Acc:MGI:109617] |
| Ensembl ID | ENSMUSG00000032033 |
| Bio databases IDs | |
| Aliases | BarH-like homeobox 2 |
| Synonyms | 2310006E12RIK, BarH-like homeobox 2, BARX homeobox 2, LOC100365792, LOC679497 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Barx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
- DNA binding
- barx basic region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- cervical cancer
- organismal death
- renal clear cell adenocarcinoma
- renal clear cell cancer
- metastasis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- breast carcinoma
role in cell
- expression in
- activation in
- proliferation
- growth
- differentiation
- migration
- invasion
- invasion by
- tumorsphere formation by
- ingestion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- actin cytoskeleton
- Golgi Apparatus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Barx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- skeletal muscle cell differentiation
- cartilage condensation
- myotube differentiation
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- actin cytoskeleton
- cytosol
- Golgi apparatus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity