Cox7a2 Gene Summary [Mouse]
Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial respirasome assembly. Located in mitochondrion. Part of respiratory chain complex IV. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; heart; hemolymphoid system; integumental system; and nervous system. Orthologous to human COX7A2 (cytochrome c oxidase subunit 7A2) and COX7A2P2 (cytochrome c oxidase subunit 7A2 pseudogene 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox7a2 |
| Official Name | cytochrome c oxidase subunit 7A2 [Source:MGI Symbol;Acc:MGI:1316715] |
| Ensembl ID | ENSMUSG00000032330 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 7A2 |
| Synonyms | COX7A3, COX7AL, COX7AL1, COXVIIAL, cytochrome c oxidase subunit 7A2, VIIAL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox7a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cyt_c_Oxidase_VIIa
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Cox7a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- Huntington disease
- chromophobe renal cell carcinoma
- chromophobe renal cancer
regulates
- p70 S6k
- testosterone
- STAR
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox7a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of oxidative phosphorylation
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
- mitochondrial respiratory chain supercomplex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial respiratory chain
- mitochondrial membrane
- mitochondrial respiratory chain complex IV
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity