Uqcrq Gene Summary [Mouse]

Involved in brain development. Located in mitochondrion. Part of respiratory chain complex III. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 4. Orthologous to human UQCRQ (ubiquinol-cytochrome c reductase complex III subunit VII). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Uqcrq
Official Name
ubiquinol-cytochrome c reductase, complex III subunit VII [Source:MGI Symbol;Acc:MGI:107807]
Ensembl ID
ENSMUSG00000044894
Bio databases IDs NCBI: 22272 Ensembl: ENSMUSG00000044894
Aliases ubiquinol-cytochrome c reductase, complex III subunit VII
Synonyms 1100001F06Rik, 1500040F11Rik, 5830407L17Rik, 9.5kDa, c1502, LOW MOLECULAR MASS UBIQUINONE binding, MC3DN4, QCR8, QP-C, ubiquinol-cytochrome c reductase complex III subunit VII, ubiquinol-cytochrome c reductase, complex III subunit VII, UQCR7, Uqcrb
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uqcrq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • UcrQ family
  • enzyme
  • protein binding

Pathways

Biological processes and signaling networks where the Uqcrq gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • chronic obstructive pulmonary disease
  • nuclear type 4 mitochondrial complex III deficiency
  • Huntington disease
  • Leigh syndrome
regulated by
role in cell
  • survival
  • morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pH resistant lipid raft fraction
  • detergent resistant lipid raft fraction
  • Mitochondria
  • mitochondrial inner membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Uqcrq gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cerebellar Purkinje cell layer development
  • midbrain development
  • pons development
  • subthalamus development
  • hippocampus development
  • cellular respiration
  • hypothalamus development
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • thalamus development
  • pyramidal neuron development

Cellular Component

Where in the cell the gene product is active
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • mitochondrial inner membrane

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.